1. Lack of energy 2. Sleep disturbance (early morning waking/difficulty getting to sleep) 3. Lack of interest in oneself and ones surroundings. 4. Lack of self esteem 5. Feelings of worthlessness, helplessness, hopelessness. 6. Withdrawal from family & friends. 7. Persistent feelings of sadness, irritability or anger. 8. Inability to cope with everyday problems 9.